Mitochondrial Matrix Phosphoproteome: Effect of Extra Mitochondrial Calcium
نویسندگان
چکیده
منابع مشابه
Identification of Mitochondrial DNA Polymorphisms That Alter Mitochondrial Matrix pH and Intracellular Calcium Dynamics
Mitochondrial DNA (mtDNA) is highly polymorphic, and its variations in humans may contribute to individual differences in function as well as susceptibility to various diseases such as Parkinson disease, Alzheimer disease, bipolar disorder, and cancer. However, it is unclear whether and how mtDNA polymorphisms affect intracellular function, such as calcium signaling or pH regulation. Here we se...
متن کاملCALL FOR PAPERS Mitochondrial Metabolism Changes in the mitochondrial phosphoproteome during mammalian hibernation
Chung DJ, Szyszka B, Brown JC, Hüner NP, Staples JF. Changes in the mitochondrial phosphoproteome during mammalian hibernation. Physiol Genomics 45: 389–399, 2013. First published April 9, 2013; doi:10.1152/physiolgenomics.00171.2012.—Mammalian hibernation involves periods of substantial suppression of metabolic rate (torpor) allowing energy conservation during winter. In thirteen-lined ground ...
متن کاملMitochondrial calcium uptake.
Calcium (Ca(2+)) uptake into the mitochondrial matrix is critically important to cellular function. As a regulator of matrix Ca(2+) levels, this flux influences energy production and can initiate cell death. If large, this flux could potentially alter intracellular Ca(2+) ([Ca(2+)]i) signals. Despite years of study, fundamental disagreements on the extent and speed of mitochondrial Ca(2+) uptak...
متن کاملChanges in the mitochondrial phosphoproteome during mammalian hibernation.
Mammalian hibernation involves periods of substantial suppression of metabolic rate (torpor) allowing energy conservation during winter. In thirteen-lined ground squirrels (Ictidomys tridecemlineatus), suppression of liver mitochondrial respiration during entrance into torpor occurs rapidly (within 2 h) before core body temperature falls below 30°C, whereas reversal of this suppression occurs s...
متن کاملMitochondrial Modulation of Calcium Signaling
Integrin crosstalk, in which ligation of one type of integrin changes the activity of another integrin on the same cell, has been observed in many cell types under a variety of conditions, but the molecular mechanism for this phenomenon has remained obscure. Now Blystone et al. (page 889) have found that the ligation of the integrin a v b 3 inhibits the activity of calcium-calmodulin kinase II ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemistry
سال: 2006
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi052475e